![]() ![]() Form testable hypotheses and articulate research objectives that, when met, will lead to significant contributions to the field of study.Demonstrate comprehensive understanding of scholarly literature in the area of study.Our students perform independent research under the guidance of top faculty investigating a diverse range of questions in the sciences of molecular, cellular and developmental biology. ![]() It really highlights how universities can drive innovation,” Benjamin Glick said.The Molecular, Cellular & Developmental Biology Interdepartmental Graduate Program at Iowa State University is a multidisciplinary major that allows students to explore the mechanisms of life processes in cutting-edge research labs. “The University of Chicago has been helpful every step of the way, and we’re very appreciative of the help we received throughout the initial commercialization process and the licensing of our software. The company’s story is an inspiring one of a faculty member recognizing an unmet need and patiently, along with his team, successfully building and delivering a product to address that need.” Over the past several years she has attended many of the Exchange’s marketing seminars, and SnapGene uses its offices for a variety of meetings – including the finalization of its transaction with Insightful Science.Įric Ginsburg, Interim Director of the Polsky Center’s Technology Commercialization team said, “We congratulate SnapGene on its success in reaching this step. When SnapGene was first being developed, the team worked with the Polsky Center’s predecessor to patent the underlying technology.Īline Glick, who serves as SnapGene’s chief product officer, is also a member of the Polsky Exchange, a 34,000 square foot startup hub in Hyde Park. Most recently, the University’s Polsky Center for Entrepreneurship and Innovation assisted Glick and his leadership team in the acquisition process with Insightful Science. SnapGene has deep roots at the University of Chicago. We perceived that there was a need, and it was clear we had an opportunity and the aptitude that would allow us to solve this widespread problem.” “Scientists can end up making mistakes that set them back days or weeks or more. “While DNA cloning is supposed to be simple, each procedure is different and there are many variables,” Glick explained. and Daphne Preuss, a previous colleague of Glick’s in the University’s Molecular Genetics and Cell Biology department who left academia to launch her own startup.Eugene Losev, a PhD student who was completing his thesis in Glick’s laboratory and moving to the business world.Aline Glick, Ben’s wife and an experienced commercial software product manager and marketer.Will Stokes, a software developer fresh out of a master’s program in Computer Graphics (and by chance a native Hyde Parker and University of Chicago Laboratory Schools graduate), whom Glick and Scott discovered through a Google search.His neighbor, Michael Scott, a professor of Mechanical Engineering at University of Illinois at Chicago, with a background in software and product design.To do that, he recruited a diverse team of scientists and technologists: Glick said the company is constantly improving the software based on intensive engagement with customers, adding that his team is thrilled to continue this work with the support of Insightful Science, a technology company with a portfolio of industry-leading solutions designed to empower scientists.īut, before a profitable company with the assets to be acquired was even a thought, Glick had to get SnapGene off the ground. It is designed for ease-of-use, while maintaining the ability to execute advanced applications. SnapGene is attractive to a diverse range of customers for several reasons. It is now used by more than 265,000 researchers in 65 countries, including leading academic institutions and commercial customers ranging from startups to biotech and pharmaceutical giants. The software providesintuitive visualization of DNA constructs, automatically documents cloning simulations, and offers a convenient way to share richly annotated molecular biology data. SnapGene is the easiest way to plan, visualize, and document molecular biology procedures. When these elements align, you end up with a company like SnapGene, a leading molecular biology software company based in Hyde Park, which announced on Tuesday, August 13 that it had been acquired by Insightful Science.įounded in 2004, SnapGene was born of frustration that founder Benjamin Glick, PhD, a faculty member in the University of Chicago’s Molecular Genetics and Cell Biology department, experienced with inefficiencies of DNA cloning in the lab. Skill, knowledge, determination, acumen and connections – along with a little luck and serendipity – all can play a part. ![]() The successful launch and longevity of a startup is often the result of several factors. ![]()
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![]() ![]() This process of calculating times between earthquakes (known as recurrence) also considers the possibility of earthquakes jumping from one fault to another, as has been observed in past earthquakes such as the 1992 M7.3 Landers earthquake in the Mojave Desert of southern California. The yearly frequencies of rupture are very low, so this is translated into a percent chance of a fault rupturing over a longer given time scale (for example, 10% in 50 years). Blue lines are normal faults (also called dip-slip faults), yellow lines are reverse faults (also called thrust faults), and red lines are strike-slip faults.Ĭombining fault locations and activity rates allows us to calculate the frequency of rupture along a given fault. Although earthquakes are rare in the central and eastern United States, they do occur and can cause damage (for example, the 2011 M5.8 earthquake in Mineral, Virginia).įault sections being used in the creation of the 2023 U.S. For example, geodesists use high-precision Global Navigation Satellite System (GNSS) instruments distributed across the western United States to determine the velocities of the Earth’s surface relative to the stable and very slowly deforming eastern United States. These activity rates can be measured both by geologists, with knowledge of how much displacement has occurred along a fault over a given length of time (like our previous example of a displaced sediment layer with a known age), and by geodesists. In addition to the fault locations, we need to know how active each fault is, which reflects how frequently a fault has earthquakes and how big those earthquakes may be. Unfortunately, earthquakes don’t just happen on mapped faults – they occur all the time in places where there is no fault on the map – but all those earthquakes are also taken into account in hazard models, as indicators of where and how often earthquakes could occur away from known faults. These observations can be made in the field or using remotely sensed imagery, like aerial imagery and other techniques. For example, if we know that a certain sediment deposit is 1,000 years old, and we see that this sediment has been cut and moved by the fault, we know that an earthquake on the fault reached the surface in the last 1,000 years. Earthquakes on these faults disrupt the surface features, and the date the earthquake occurred can be estimated by the age of the disrupted features. The location of faults is known through observations of topographic and landscape disruptions caused by movement on said faults. ![]() Faults and EarthquakesĮxisting faults and locations of past earthquakes are the starting point for a seismic hazard model. Larger versions of each photo can be found at: 2001 M6.8 Nisqually, Washington, 2014 M6.0 South Napa, California, 1994 M6.7 Northridge, California, 1975 M7.7 Kalapana, Hawaii, 2011 M5.8 Mineral, Virginia, and 2018 M7.1 Anchorage, Alaska. Damage from various earthquakes around the U.S. Let’s look at what goes into the NSHM in more detail to better appreciate the improvements and progress for the 2023 model.Ī map from the 2018 United States Seismic Hazard Model showing highest hazard in red and lowest hazard in gray. The USGS is currently working on the updated hazard model for the 50 states targeted for completion and release in 2023. The distinction between hazard and risk is that hazard refers to natural phenomena from earthquakes (e.g., ground shaking), whereas risk refers to consequences of the hazard (e.g., dangers the hazard poses to life and property). The model and related maps have a surprising variety of uses, from guiding engineering design of structures to helping determine earthquake insurance rates, and informing government officials, emergency managers, and public officials about potential risks to their communities. Additionally, engineering analyses inform us about how built structures could react to the ground shaking forecasted by the model. Geological Survey (USGS) uses the most current data and state-of-the-art forecasting methods to create an updated National Seismic Hazard Model (NSHM). Faults, earthquakes and geology – are the ingredients that go into making a seismic hazard model. ![]() ![]() ![]() Kia Stinger Hatchback (2017 - 2021) review. Detections are enhanced to cover new variants, optimize performance, and correct incorrect identifications. Stinger McAfee Stinger is a standalone utility used to detect and remove specific viruses. ChangesĮnhanced detections are those that have been modified for this release. Detections are enhanced to cover new variants, optimize performance, and correct incorrect identifications. It's a niche tool that any tech would want to have on their thumb drives, etc. McAfee Stinger is not a stand-alone antivirus product to protect your system but more of a specialized tool to try to remove viruses from already infected systems. Video tutorial and portable version available. Stinger - low-key, focused virus detection.Įnhanced detections are those that have been modified for this release. McAfee Stinger detects and removes specific viruses. If you are experienced, however, you'll find Stinger to be a helpful tool in your antivirus toolbox. Stinger is not a user-friendly program, but then again, it's not developed for your average user. The Stinger configuration options are limited and quite advanced - you'll be able to specify what you want the program to do when it finds a virus, if you want to see a list of scanned files on the interface and an assortment of options relating to virus detection. By default, Stinger will repair any viruses it finds, and you can export scan results under the File menu. Worry-free protection for your privacy, identity and all your personal devices. The program works quickly, summarizing results in the interface window. ![]() Add the paths that you want to scan and hit the red Scan Now button. ![]() ![]() ![]() Racters from King Pig do not have a plush yet. The Mighty Eagle is the most expensive plush, probably because it only comes in one size.The Helmet Pig is the only pig plush that is beaten up. In Angry Birds Space, the Angry Birds appear as the Space Flock.At the start of the events of the game, they were taking care of their eggs as usual, until they spotted a wormhole in the sky and, falling from it, Ice Bird and an eggsteroid.The Hockey Bird plush is not available in any websites or shops, but it can be found here. WORKS Angry Birds 5' Plush Bubbles Orange Bird Oriole 2012 Commonwealth Rovio.The Mighty Eagle, Marmoset, Hockey Bird and Nerdy Birdy are the only plushies to be released without any others along with it.The first release of the 5" Boomerang Bird, White Bird, most pigs (except Mustache Pig, Chef Pig and Cowboy Pig) and inflated Orange Bird are the only plushies with open mouths.The third release of Boomerang Bird looks like he does in Angry Birds Rio. Angry Birds Hatchlings Plush Orange Stuffed Animal Fat Bird Adorable Lovey 2018. The old version of Boomerang Bird has an open beak. Angry Birds Star Wars, a crossover between the Star Wars franchise and the Angry Birds series of video games, launched on November 8, 2012.The new version doesn't have a white spot. ![]() The old version of the Black Bird plush toy had a white spot on its forehead, as it does in the games.Start Free Trial or Sign In to see what its worth. Black Bird and Boomerang Bird are the only plushies to go through design changes. Angry Birds Bubbles Plush Bookbag Backpack Clip Yellow Orange Globe Doll NEW Sold for. ![]() ![]() Stuart has approaches available to allow those students to participate. In the three years he has been using this approach he has only had two students (out of hundreds) who genuinely didn't have access to the technology. He acknowledges that the issue of accessibility and equality has been raised, but the reality he has experienced is that after clearly stating his intention to use this technology and stating that the students would gain most out of these by having multiple devices, that students generally bring two devices. Students can always still participate with one device but it makes it harder. He expects all students to have access to one device and ideally two, e.g. He states that his course requires students to be technologically engaged. Now you have a single-click option to generate an optimized version of a PDF file directly from the File menu in. He approaches this by explicitly asking his class to bring two devices each. It also requires the students to engage with multiple technologies for their in-class learning. ![]() Even though he has been using these technologies for a couple of years now he still finds that it can be challenging to manage everything in a class setting, and controlling visibility of his PowerPoint slides, GoSoapBox responses and Notable takes some preparation and management whilst teaching. Stuart is now developing his thinking around how he will use this with his students this year, and with some new features introduced he's keen to include and explore some other aspects. He also encouraged students to engage with the material by putting explicit questions within Notable about the slide to help and guide the student note taking process and to prompt their extended thinking. Notable was a way of acknowledging the positives of the student request by using it with selective slides. The idea of encouraging effective notetaking to aid students' learning was also an important driver. He was using class response systems ('clickers' and ' gosoapbox') during the lecture and wanted to ensure that any answers and the value of active discussion were not wasted. He would have normally just made his slides available after the class. Step 3: Drag and drop the changes on the uploaded PDFs on the right side of the screen and finally save the changes. ![]() Step 2: Click the 'Annotate' option from the drop-down menu and choose the respective edit tools from the left pane of the screen. ![]() Stuart had resisted just putting up his full PowerPoint slides up into Blackboard before the lecture as there was some content he wanted to withhold from the students until the lecture time, to allow formative feedback and interactive elements in class to supplement the content. Step 1: Download the PDF from Google Drive to the working space of the Kami PDF Editor. Student demands were growing for him to put up the class slides / notes onto Blackboard before classes, so that they could print them off and use them for note taking. Stuart had been grappling with the question of "What notes do I put online for my students?". ![]() ![]() ![]() Check these Endo Z safety tip bur in tungsten carbide. 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Delivery costs are carefully determined in the shopping cart and will be added to the request total before checkout.ĭental Prod will in any case bend over backwards to state your purchase as indicated by the assessed convention bar, we will state within the allocation at the moment that in case of unforeseen circumstances beyond our ability to control Not sure. ![]() Delivery costs are estimated by your entire request and your area estimate and weight. Contingent on your area, requests may take up to 7 days to arrive.Īll bundles/bundles are conveyed by reputed external courier administration. When your request is received, it will be sent within 24 hours. It is your duty to protect your MasterCard subtlety and not to expose your microcosm to allow improper use.īefore reaching or returning to anything, we must reach our office. It is your responsibility to maintain the confidentiality of your records and access to your PC or gadget. 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Give a restricted "unconditional promise" return on dental prod products. ![]() ![]() The good news is that there's a 90-day free trial available so you can figure out if the platform works for you before you buy.Įlectronic Music Producers: The ease of use that Logic Pro brings to the table makes it perfect for garage band musicians and songwriters looking to dive into making their own recordings. There's no recurring subscription fee, but it does require more of an up-front investment. Pro Tools also offers a "Pro Tools Ultimate" version with additional toolsĪbleton Live works on the software ownership model, with their most basic platform available for $99, but if you want the full platform, it'll cost you $749. However, this price plummets to just $99 per year with qualifying academic eligibility for students and teachers. Why: It's hard to determine a winner for price between these two programs because they use very different pricing models.Īvid Pro Tools uses a subscription-based model, starting at $299 for a 1-year subscription paid up-front. This just reflects that overall, these are both two extremely high-quality DAWs that are nearly equally loved by their users. Why: Capterra users rated Ableton Live 4.9/5 stars, while Pro Tools came in slightly under at 4.8/5 stars. Both ratings put these programs at the top of the market, but in this case, G2 reviewers found Ableton Live to have a slight edge over Avid Pro Tools in areas such as ease of use, ease of setup, ease of admin, and ease of doing business. ![]() Why: G2, one of the most trusted sources for software reviews, rated Ableton Live as a solid 4.7/5 stars, while Avid Pro Tools only scored 4.3/5. It has a vibrant support community, tons of learning videos, and a technical support team on standby to help you through any challenges you may be facing with the platform. Why: Overall, users have rated Ableton Live's support quality higher than that of Pro Tools. ![]() ![]() From automation tools to live loop options and tons of plug-ins, Ableton Live is a mixers playground. As a platform mainly designed for EDM producers, sound mixing is something that Ableton has prioritized in its features setup. Why: Ok, now we're in Ableton Live's wheelhouse. The recording interface is much more intuitive to operate and the proprietary multi-tool makes editing on the fly during a recording session a breeze. After years of experience as an industry standard, Pro Tools has honed in on making live recording easy. Why: This is another area where Pro Tools excels. If you're looking to do exact waveform edits, this is an area where Pro Tools excels. 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For example, Pro Tools has focused heavily on meeting the needs of people who do many live audio recordings and sampling. While Avid Pro Tools and Ableton Live share many similarities, they also have some key differences. ![]() The Main Differences Between Avid Pro Tools and Ableton This is why there is so much debate over which platform works best for which producers. Both work with midi, have all the features needed to record and manipulate audio clips to your heart's content, host plugins, and export in a variety of formats. Avid Pro Tools and Ableton are both DAWs used to record, produce, and mix audio projects. ![]() ![]() Sure, of course, you can obtain it without spending a dime, however in smaller amounts - for example, you get one crystal after each influx you achieved. ![]() which offer you a big profit.Ĭrystals are manner harder to get than yellow metal. You can spend your made gold on all you need - homes, soldiers and many more. 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Grow castle is exceptional cell game when you ought to safeguard your citadel and beat lots of monsters. Appears to be good, proper? So just now go and check grow castle hack. Now you've got an possibility to attain as much resources as you want way to your internet-primarily founded, clean to work with generator. ![]() In the event you desire to be the wonderful participant or just accomplish every influx plenty enough easier you could't miss that. Are you need to get an infinite amount of platinum and crystals? You don't have to spend many time so you can achieve these resources? We expose you, our grow castle hack. ![]() ![]() ![]() ![]() Adriana has the ability to make an impact as we strengthen this special group with her talent to help continue to push us forward." "She wants to be here and take advantage of the opportunity in a competitive environment ahead of the World Cup. "An opportunity was presented to us to bring Adriana to Portland, and we believe this is a move that is beneficial for both the club and Adriana," said Thorns general manager Karina LeBlanc. Canadian international Adrianna Leon will join the club on short-term loan from Manchester United pending the receipt of her P-1 visa and international transfer certificate. The franchise has now added another scoring threat to the team. Thorns forward Sophia Smith, the 2022 NWSL MVP, already has four of the team's goals to start this year. The 2022 NWSL Champions are still the team to beat, with eight goals scored through their opening two matches and back-to-back wins. Houston Dash: The Thorns have an early grasp on first place but that could change after the weekend. on Paramount+ and CBS Sports Golazo Network Take a look at the upcoming slate of games: NWSL Week Three Fans can watch the NWSL regular season across CBS Sports platforms and Paramount+. Week three concludes on Saturday with a quintet of matches as all 12 clubs continue to build on their early season performances. The action begins on Friday as first-place Portland Thorns FC host fourth-place Houston Dash. The 2023 National Women's Soccer League regular season returns after an international break with a full slate this weekend. ![]() ![]() ![]() The external membrane expresses a potent immune response inducer, lipopolysaccharide (LPS), which is composed of three units: a hydrophilic polysaccharide, O antigen, and a hydrophobic domain known as lipid A. GNB have two membranes, an external and an internal. Some of the mechanisms of resistance include efflux pumps, alteration of the drug binding site and membrane permeability, degradation enzymes, and the conformational change of the drug culminating in its inactivation. These organisms have a range of mechanisms to prevent the action of many antimicrobials used in clinical medicine. Sulfamethoxazole-trimethoprim remains the mainstay of treatment. These mechanisms, associated or separate, restrict the treatment options to an alarming level. Thus, Stenotrophomonas present several efflux pumps and produce two carbapenemases – L1 (resistance to all carbapenems) and L2 (cephalosporinase). The Stenotrophomonas exhibit a pattern of intrinsic multi-resistance, especially in patients who have had contact with carbapenems. The genetic ingenuity of this microorganism goes further, and it combines high impermeability with genetic plasticity, combining with the resistance of mechanisms such as extended-spectrum b-lactamases (ESBL). The most frequent are MexAB-OprM and loss of OprD (which gives impermeability to the bacterial cell due to the loss of porin.) Acinetobacter baumannii naturally produces AmpC cephalosporinase and oxacillinase (OXA), leaving it spontaneously immune to many drugs. aeruginosa, cephalosporinase of type AmpC, and efflux systems that confer resistance to b-lactams. The critical issue regarding BNF, when it comes to the antimicrobial sensitivity profile, is undoubtedly their intrinsic resistance since they produce a variety of genes with multiple mechanisms capable of mitigating the microbicidal action. The main BNF microorganisms that cause human disease are Pseudomonas aeruginosa, Acinetobacter baumannii, Burkholderia cepacia, Burkholderia pseudomallei, Stenotrophomonas., Alcaligenes, and Moraxella. These stand out for being aerobic and non-sporulated they are incapable of fermenting sugars, using them through the oxidative route. ![]() They also cause opportunistic diseases in ICU patients who undergo invasive procedures. The non-fermenter, gram-negative bacilli (BNF) have a lower frequency of isolation when compared to Enterobacteriaceae however, they are a relevant group since they cause severe, fatal infections, especially in the hospital environment. ![]() Laboratory characterization is an essential component when it comes to microorganisms therefore, it is imperative to expose characteristics of Enterobacteriaceae, which are bacilli, non-sporulated, have variable motility, grow in the presence and absence of oxygen, ferment organisms of glucose, are cytochrome oxidase negative, and can reduce nitrate to nitrite. The general/species that frequently affect humans are Escherichia, Proteus, Enterobacter, Klebsiella, Citrobacter, Yersinia, Shigella, and Salmonella, among others. They account for about 80% of gram-negative isolates with a myriad of disease-causing general/species in humans, including urinary tract infections, pneumonia, diarrhea, meningitis, sepsis, endotoxic shock, and many others. Two large groups, Enterobacteriaceae and the non-fermenters, are responsible for most clinical isolates nevertheless, other clinically concerning gram-negative organisms exist, including but not limited to Neisseria, Haemophilus spp., Helicobacter pylori, and Chlamydia trachomatis.Įnterobacteriaceae are a heterogeneous group widely dispersed in nature. These microorganisms have significant clinical importance in hospitals because they put patients in the intensive care unit (ICU) at high risk and lead to high morbidity and mortality. Gram-negative bacteria (GNB) are among the world's most significant public health problems due to their high resistance to antibiotics. ![]() |
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